Interrogation of Streptomyces avermitilis for efficient production of avermectins
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Interrogation of Streptomyces avermitilis for efficient production of avermectins
The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin, respectively. Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents. Because wild-type strains only produce low levels of avermectins, much research effort has focused on improvements in avermectin production to meet the ever increasing demand for...
متن کاملRaising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs)
Avermectins, a group of anthelmintic and insecticidal agents produced from Streptomyces avermitilis, are widely used in agricultural, veterinary, and medical fields. This study presents the first report on the potential of using nanosecond pulsed electric fields (nsPEFs) to improve avermectin production in S. avermitilis. The results of colony forming units showed that 20 pulses of nsPEFs at 10...
متن کاملReverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.
Avermectin and its analogues are produced by the actinomycete Streptomyces avermitilis and are widely used in the field of animal health, agriculture, and human health. Here we have adopted a practical approach to successfully improve avermectin production in an industrial overproducer. Transcriptional levels of the wild-type strain and industrial overproducer in production cultures were monito...
متن کاملProduction of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis.
6,8a-deoxy derivatives of avermectins produced by a mutant strain of Streptomyces avermitilis K20571} derived by mutation from strain K2038 producing avermectins B l a and B2a selectively2). The parent strain K2038 carries two types of mutations, C-5 0-methylation (aveD) and the selective incorporation of branched-chain fatty acid into the avermectin molecule (X). The mutant strain K2057 has an...
متن کاملfaciliting lexical access for the fluent production of speech
the hypothesis is that recent and frequent exposure to lexical items leads to a more fluent production of speech in terms of rate of speech. to test the hypothesis,a one-way anova experimental design was carried out. 24 sednior students of efl participated in a one-way interview test. data analyses revealed that those who were exposed frequently to the lexical items over a week prior to inter...
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ژورنال
عنوان ژورنال: Synthetic and Systems Biotechnology
سال: 2016
ISSN: 2405-805X
DOI: 10.1016/j.synbio.2016.03.002